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Analysis was performed using the LC-20 Prominence HPLC system (Shimadzu, Kyoto, Japan) coupled to a LTQ Orbitrap XL Hybrid Ion Trap-Orbitrap Mass Spectrometer (Thermo Fisher Scientific) according to 1 ) with a mixture of water and acetonitrile, both containing 0.1% formic acid
In the U.S., the maximum legal BAC for driving is 0.08%, though some jurisdictions set lower limits
doi: 10.1016/S0378-5173(03)00183-2
According to the results from in vitro and in vivo studies, tanshinone IIA pretreatment protects the liver from APAP-induced liver injury by activating Nrf2 and increasing the mRNA and protein levels of the Nrf2 target genes glutamate-cysteine ligase catalytic subunit (GCLC), NQO1, and HO-1 (Wang et al., 2016)
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